The appearance of acute kidney injury, even if transient, predicts worse cardiac outcomes and higher mortality in affected patients.
Euro-CRIPS, the European and Chinese cardiac and renal Remote Ischemic Preconditioning Study1, showed that remote ischemic preconditioning (RIPC) prior to percutaneous coronary intervention (PCI) protected the patient from contrast-induced nephropathy (CIN).
This multi-centre, double-blind randomized controlled trial enrolled 223 patients with moderate (Stage 3) kidney disease. Patients received standard of care treatment with or without RIC treatment.
Hospitalization length, which is known to be increased in patients with CIN, was also reduced by RIC treatment (mean hospital stay 3.2 days vs. 2 days, p=0.05).